Date : 25/03/2009

Laboratory
Epigenomics Project
CNRS UPS3201
Tour Evry2, étage 10 523,
Terrasses de l'Agora
91034 EVRY Cedex
Director : Francois Kepes

PhD Supervisor
Alfonso Jaramillo
email : Cet e-mail est protégé contre les robots collecteurs de mails, votre navigateur doit accepter le Javascript pour le voir
phone : +33 1 69 47 44 44

Subjects / Tools-Methodologies:
1 : mathematical modeling / software development
2 : computational design / software development
3 : bioimaging / microfluidics

Summary of lab's interests

Mathematical modeling, computational design, synthetic biology, image processing, microfluidics, protein design, transcriptional networks, metabolic networks.

Summary of project

The project will focus on using mathematical modelling of genetic oscillators to engineer gene networks with targeted behavior. The student will improve our methodology for automatic computational design of genetic oscillators, which will allow the engineering of tunable and robust genetic devices. He will implement them in E. coli and he will characterize them utilising a nano-chemostat device, also developed by the student. He will use the data obtained this way to create and fine-tune a concise mathematical model of the mechanism of genetic oscillations.