Date : 23/01/2012

Laboratory
Systems Epigenomics
INSERM U955 INSERM / UPEC / CNRS
Institut Mondor de Recherche Biomédicale - Vaccine Research Institute
94010 Créteil
Website
Main discipline : Systems Biology
Lab director : Georges Guellaen

PhD Supervisor
Arndt Benecke
email : This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
phone: +33 1 60 92 66 65

Subjects
1.: non-coding RNA
2.: chromatin
3.: HIV transcription, latency

Tools and Methodologies
1.: Next generation sequencing
2.: bioinformatics
3.: biochemistry

Summary of lab's interests
Gene expression regulation, chromatin, viromics, host-pathogen interactions. http://www.ncbi.nlm.nih.gov/pubmed?term=benecke%20a

Summary of project
This project will use state-of-the-art deep sequencing technology to systematically identify and characterize small non-coding RNAs in chromatin regulation. Particular interests are focused on chromatin dynamics in HIV infection and latency and viral reactivation. Several human and non-human primate models will be combined to generate a comprehensive view of non-coding RNA dynamics and their regulatory role in these processes.

Interdisciplinarity of the project
This project combines genome-wide high-throughput analysis with RNA biochemistry and an substantial amount of bioinformatics and modeling.

Do you have an available funding for this project ?
This project is partially funded through the NIH/NIAID.