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Novel biopolymer nanocomposite hydrogels for tissue engineering

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Date : 04/04/2011

Laboratory
Matière et Systèmes Complexes (MSC)
UMR 7057 CNRS Paris-Diderot
Batiment Condorcet case 7056
Université Paris Diderot
10 rue Alice Domon et Léonie Duquet
75205 Paris cedex 13
Website : http://www.msc.univ-paris-diderot.fr
Main disciplin : Physics
Director : Loïc Auvray

PhD Supervisor
Alain Ponton
email : This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
phone : + 33 1 57 27 61 96

Subjects
1.: Nanocomposites
2.: Biotechnology
3.: Engineering tissue

Tools and methodologies
1.: Synthesis of nanoparticles and nanocomposites biomaterials
2.: Mechanical study
3.: Bioactivity

Summary of lab's interests

The laboratory ''Matières et Systèmes Complexes'' offers novel research studies by putting together tools and expertise from fundamental and applied research between physics, biology and medicine. The strategy of the laboratory is to promote the interdisciplinarity (physico-chemistry, mechanics, non linear physics, biology, statistical physics) in order to progress in the comprehension of dynamic and interfacial properties of complex systems as well as for fundamental research aspects as for technological applications.

Summary of project

The objective of this project is to develop new nanocomposite biopolymers based materials by combining chemical compatibility with physiologically appropriate mechanical properties for use for both implants and substrates for tissue engineering. Networks based on natural polymers are three-dimensional networks particularly suitable compared to conventional non-aqueous polymers due to their exceptional biocompatibility for tissue engineering. The introduction of inorganic nanoparticles is expected to modulate the mechanical properties of these biopolymers and to provide any functionality (bactericidal properties, magnetic delivery of active molecules magnetically driven ...) for optimize cell regeneration.

Interdisciplinarity of the project

The success of the development and characterization of nanocomposites materials considered in this project would validate their ability to provide original different types of supports and / or implants for human tissue repair surgery. This study will need chemical, physical and biological skills and the capacity to collaboarte with different teams of physicists, chemists, biologists and physicians.